Svetlana V. Ukraintseva, PhD, is Senior Research Scientist at the Center for Population Health and Aging (CPHA), Duke University. She is aging researcher with extensive backgrounds in human biology, genetics, and epidemiology, allowing her to apply integrative approaches to such complex topic as understanding mechanisms of human aging and relationships between aging, health and longevity. . Particular research interests of Dr. Ukraintseva include: (i) Common and unique genetic factors in aging, health decline and longevity. . (ii) Polygenic and pleiotropic genetic effects (including trade-offs). Age-specific influence of genes on longevity, risks of diseases, and aging phenotypes. . (iii) Diseases and their genetic risk factors that are consistent with improved survival and/or slower aging. . (iv) Relationships between aging and cancer. . (v) Genetic regulation of the slowdown in metabolic, proliferative and information processing responses to stresses during aging. . ______________________________________________________________________________________________________________________________ Dr. Ukraintseva majored in Biology and Genetics. Her PhD was in genetic epidemiology of complex diseases. As a postdoctoral fellow and then Research Scientist at Max Plank Institute (Germany), she carried out studies on cancer epidemiology, common genes in aging and cancer, non-monotonic and pleiotropic effects of aging on risks of diseases and lifespan, and on the role of changes in physiological aging process in global increases in cancer risk and longevity. . In her current work at the CPHA, Dr. Ukraintseva continues to investigate complex relationships among genetic and non-genetic factors that influence aging, health decline and longveity, using large sets of longitudinal human data (such as Framingham Study, CHS, MESA, WHI, NLTCS, LSADT, and other), containing rich genetic and phenotypic information about thousands of individuals. . Dr. Ukraintseva’s research resulted in more than 70 peer-reviewed publications in respective fields. . ______________________________________________________________________________________________________________________________ Selected Publications: . 1. Yashin AI, Wu D, Arbeev KG, Ukraintseva SV. Polygenic Effects of Common Single-Nucleotide Polymorphisms on Life Span: When Association Meets Causality.Rejuvenation Res. 2012 Apr 25. [Epub ahead of print] PubMed PMID: 22533364. . 2. Kulminski AM, Culminskaya I, Ukraintseva SV, Arbeev KG, Arbeeva L, Wu D, Akushevich I, Land KC, Yashin AI. Trade-off in the effects of the apolipoprotein E polymorphism on the ages at onset of CVD and cancer influences human lifespan. Aging Cell. 2011 Feb. PMCID: PMC3094490. . 3. Yashin AI, Wu D, Arbeev KG, Ukraintseva SV. Joint influence of small-effect genetic variants on human longevity. Aging (Albany NY). 2010 Aug 26. PMCID: PMC2984609. . 4. Ukraintseva SV, Arbeev KG, Akushevich I, Kulminski A, Arbeeva L, Culminskaya I, Akushevich L, Yashin AI. Trade-offs between cancer and other diseases: do they exist and influence longevity? Rejuv Res. 2010, Aug;13(4):387-96. PMCID: PMC2959185. . 5. Ukraintseva SV, Arbeev KG, and Yashin AI. Epidemiology of Hormone-Associated Cancers as a Reflection of Age. In: Innovative Endocrinology of Cancer. Series: Advances in Experimental Medicine and Biology, Berstein, LM.; Santen, RJ. (Eds.). Springer and Landes Bioscience: 2008, Vol. 630: 57-71. . 6. Ukraintseva S, Sloan F, Arbeev K, and Yashin A. Increasing Rates of Dementia at Time of Declining Mortality from Stroke. Stroke, 2006, 37(5): 1155 - 1159. PMID: 16601210. . 7. Anisimov VN, Ukraintseva SV (co-first author), Yashin AI. Cancer in rodents: Does it tell us about cancer in humans? Nature Reviews Cancer, 2005 Oct; 5(10):807-19. PMID: 16195752. Invited paper. . 8. Ukraintseva SV. “Bad” in the Young – “Good” in the Old: Is This Consistent with the Antagonistic Pleiotropy Concept? (on Dr. G.M. Martin’s "How is the evolutionary biological theory of aging holding up against mounting attacks?") American Aging Association Newsletter, April 2005, p.4-5 www.americanaging.org/news/apr05.html . . 9. Ukraintseva SV, Yashin AI. Treating cancer with embryonic stem cells: Rationale comes from aging studies. Frontiers in Bioscience, 2005, 10: 588-595. PMID: 15569600 . 10. Ukraintseva SV, Yashin AI. Individual aging and cancer risk: How are they related? Demographic Research, 2003, 9-8: 163-196. DOI:10.4054. . 11. Ukraintseva S.V. Aging and the Subjective Sense of Time. In: Current Concepts in Experimental Gerontology. Ed. By C.Bertoni-Freddari, H. Niedermueler, Wien: Facultas Universitatsverlag, 2001, pp.243-249. 12. Ukraintseva S.V., Yashin A.I. How individual aging may influence human morbidity and mortality patterns. Mech. Aging & Development, 2001,122: 1447-1460. PMID: 11470132.