Harvey Jay Cohen
Member of the Duke Cancer Institute
Faculty Research Scholar of DuPRI's Center for Population Health & Aging
Director, Center for the Study of Aging & Human Development
Walter Kempner Professor of Medicine, in the School of Medicine
Professor of Medicine
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Overview
Dr. Cohen's research program includes clinical research relating to aspects of the pathways to functional decline with aging, geriatric assessment, and cancer in the elderly.
Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status.
Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen is co-chair of the Cancer in the Elderly Committee of Cancer and Acute Luekemia Group B (CALGB). A number of active studies and ongoing data bases aree being utilized to address these questions.
Publications
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Berger, M; Nadler, JW; Browndyke, J; Terrando, N; Ponnusamy, V; Cohen, HJ; Whitson, HE; Mathew, JP (2015). Postoperative Cognitive Dysfunction: Minding the Gaps in Our Knowledge of a Common Postoperative Complication in the Elderly.. Anesthesiology Clinics, 33 (3), 517-550.
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Belsky, DW; Caspi, A; Houts, R; Cohen, HJ; Corcoran, DL; Danese, A; Harrington, H; Israel, S; Levine, ME; Schaefer, JD; Sugden, K; Williams, B; Yashin, AI; Poulton, R; Moffitt, TE (2015). Quantification of biological aging in young adults.. Proceedings of the National Academy of Sciences of the United States of America, 112 (30),
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Koenig, HG; Pearce, MJ; Nelson, B; Shaw, SF; Robins, CJ; Daher, NS; Cohen, HJ; Berk, LS; Bellinger, DL; Pargament, KI; Rosmarin, DH; Vasegh, S; Kristeller, J; Juthani, N; Nies, D; King, MB (2015). Religious vs. conventional cognitive behavioral therapy for major depression in persons with chronic medical illness: a pilot randomized trial.. The Journal of Nervous and Mental Disease, 203 (4), 243-251.
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Pearce, MJ; Koenig, HG; Robins, CJ; Nelson, B; Shaw, SF; Cohen, HJ; King, MB (2015). Religiously integrated cognitive behavioral therapy: a new method of treatment for major depression in patients with chronic medical illness.. Psychotherapy (Chicago, Ill.), 52 (1), 56-66.
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Kenzik, KM; Morey, MC; Cohen, HJ; Sloane, R; Demark-Wahnefried, W (2015). Symptoms, weight loss, and physical function in a lifestyle intervention study of older cancer survivors.. Journal of Geriatric Oncology, 6 (6), 424-432.
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Wang, X; Gu, L; Zhang, Y; Sargent, DJ; Richards, W; Ganti, AK; Crawford, J; Cohen, HJ; Stinchcombe, T; Vokes, E; Pang, H (2015). Validation of survival prognostic models for non-small-cell lung cancer in stage- and age-specific groups.. Lung Cancer (Amsterdam, Netherlands), 90 (2), 281-287.
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Price, E; Artz, AS; Barnhart, H; Sapp, S; Chelune, G; Ershler, WB; Walston, JD; Gordeuk, VR; Berger, NA; Reuben, D; Prchal, J; Rao, SV; Roy, CN; Supiano, MA; Schrier, SL; Cohen, HJ (2014). A prospective randomized wait list control trial of intravenous iron sucrose in older adults with unexplained anemia and serum ferritin 20-200 ng/mL.. Blood Cells, Molecules, and Diseases, 53 (4), 221-230.
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(2014). A prospective randomized wait list control trial of intravenous iron sucrose in older adults with unexplained anemia and serum ferritin 20-200ng/mL. Blood Cells, Molecules, and Diseases, 53 (4), 221-230.
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Henderson, TO; Ness, KK; Cohen, HJ (2014). Accelerated aging among cancer survivors: from pediatrics to geriatrics.. American Society of Clinical Oncology Educational Book. American Society of Clinical Oncology. Meeting,
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Faul, LA; Luta, G; Sheppard, V; Isaacs, C; Cohen, HJ; Muss, HB; Yung, R; Clapp, JD; Winer, E; Hudis, C; Tallarico, M; Wang, J; Barry, WT; Mandelblatt, JS (2014). Associations among survivorship care plans, experiences of survivorship care, and functioning in older breast cancer survivors: CALGB/Alliance 369901. Journal of Cancer Survivorship : Research and Practice, 8 (4), 627-637.