3502 Blue Zone Duke Clinic, Center for Aging, Trent Drive
Durham, NC 27710
Duke Box 3003
Durham, NC 27710
Harvey Jay Cohen
Walter Kempner Professor of Medicine, in the School of Medicine
M.D., State University of New York at Brooklyn (1965)
Pathways to functional decline are being explored through the NIA funded Claude Pepper Older Americans Independence Center, and includes studies of the contributions of age related physiologic change, in particular changes in inflammatory parameters, comorbid diseases and conditions, environment, genetics, and the interactionas among them. Data are derived from several current studies as well as previously collected data sets from the Established Populations for Epidemiologic Studies of the Elderly (EPESE), National Long Term Care Survey, and the Chinese Longevity Study (with Dr. Zeng Yi). Previous work has demonstrated the important contributions of age related inflammation and coagulation activation to functional status.
Geriatric assessment approaches have been studied in a number of randomized and controlled studies and work is now concentrating on the application of Comprehensive Geriatric Assessment tools to the evaluation and treatment of elderly patients with cancer. This is an extension and continuation of a long standing interest in geriatric oncology. Previous studies have elucidated age-related patterns of disease presentation, treatment approaches, clinical trials, survivorship, quality of life, impact of comrobidities and functional outcomes. Dr. Cohen is co-chair of the Cancer in the Elderly Committee of Cancer and Acute Luekemia Group B (CALGB). A number of active studies and ongoing data bases aree being utilized to address these questions.
Freedman, RA; Seisler, DK; Foster, JC; Sloan, JA; Lafky, JM; Kimmick, GG; Hurria, A; Cohen, HJ; Winer, EP; Hudis, CA; Partridge, AH; Carey, LA; Jatoi, A; Klepin, HD; Citron, M; Berry, DA; Shulman, LN; Buzdar, AU; Suman, VJ; Muss, HB (2017). Risk of acute myeloid leukemia and myelodysplastic syndrome among older women receiving anthracycline-based adjuvant chemotherapy for breast cancer on Modern Cooperative Group Trials (Alliance A151511).. Breast Cancer Research and Treatment, 161 (2), 363-373.
Peterson, MJ; Thompson, DK; Pieper, CF; Morey, MC; Kraus, VB; Kraus, WE; Sullivan, P; Fillenbaum, G; Cohen, HJ (2016). A Novel Analytic Technique to Measure Associations Between Circulating Biomarkers and Physical Performance Across the Adult Life Span.. Journals of Gerontology: Series A, 71 (2), 196-202.
Kraus, WE; Pieper, CF; Huffman, KM; Thompson, DK; Kraus, VB; Morey, MC; Cohen, HJ; Ravussin, E; Redman, LM; Bain, JR; Stevens, RD; Newgard, CB (2016). Association of Plasma Small-Molecule Intermediate Metabolites With Age and Body Mass Index Across Six Diverse Study Populations.. Journals of Gerontology: Series A, 71 (11), 1507-1513.
Williams, GR; Mackenzie, A; Magnuson, A; Olin, R; Chapman, A; Mohile, S; Allore, H; Somerfield, MR; Targia, V; Extermann, M; Cohen, HJ; Hurria, A; Holmes, H (2016). Comorbidity in older adults with cancer.. Journal of Geriatric Oncology, 7 (4), 249-257.
Cases, MG; Frugé, AD; De Los Santos, JF; Locher, JL; Cantor, AB; Smith, KP; Glover, TA; Cohen, HJ; Daniel, M; Morrow, CD; Moellering, DR; Demark-Wahnefried, W (2016). Detailed methods of two home-based vegetable gardening intervention trials to improve diet, physical activity, and quality of life in two different populations of cancer survivors.. Contemporary Clinical Trials, 50 201-212.
Hodes, RJ; Sierra, F; Austad, SN; Epel, E; Neigh, GN; Erlandson, KM; Schafer, MJ; LeBrasseur, NK; Wiley, C; Campisi, J; Sehl, ME; Scalia, R; Eguchi, S; Kasinath, BS; Halter, JB; Cohen, HJ; Demark-Wahnefried, W; Ahles, TA; Barzilai, N; Hurria, A; Hunt, PW (2016). Disease drivers of aging.. Annals of the New York Academy of Sciences, 1386 (1), 45-68.
Lichtman, SM; Cirrincione, CT; Hurria, A; Jatoi, A; Theodoulou, M; Wolff, AC; Gralow, J; Morganstern, DE; Magrinat, G; Cohen, HJ; Muss, HB (2016). Effect of Pretreatment Renal Function on Treatment and Clinical Outcomes in the Adjuvant Treatment of Older Women With Breast Cancer: Alliance A171201, an Ancillary Study of CALGB/CTSU 49907.. Journal of Clinical Oncology, 34 (7), 699-705.
Pearce, MJ; Koenig, HG; Robins, CJ; Daher, N; Shaw, SF; Nelson, B; Berk, LS; Belinger, D; Cohen, HJ; King, MB (2016). Effects of Religious Versus Conventional Cognitive-Behavioral Therapy on Gratitude in Major Depression and Chronic Medical Illness: A Randomized Clinical Trial. Journal of Spirituality in Mental Health, 18 (2), 124-144.
Koenig, HG; Pearce, M; Nelson, B; Shaw, S; Robins, C; Daher, N; Cohen, HJ; King, MB (2016). Effects of religious vs. standard cognitive behavioral therapy on therapeutic alliance: A randomized clinical trial.. Psychotherapy Research, 26 (3), 365-376.
Pang, HH; Wang, X; Stinchcombe, TE; Wong, ML; Cheng, P; Ganti, AK; Sargent, DJ; Zhang, Y; Hu, C; Mandrekar, SJ; Redman, MW; Manola, JB; Schilsky, RL; Cohen, HJ; Bradley, JD; Adjei, AA; Gandara, D; Ramalingam, SS; Vokes, EE (2016). Enrollment Trends and Disparity Among Patients With Lung Cancer in National Clinical Trials, 1990 to 2012.. Journal of Clinical Oncology,