A new paper from the Moffitt & Caspi Lab published in Psychological Medicine presents replicated evidence showing that people with schizophrenia exhibit a faster pace of whole-body biological aging compared with controls, as measured using a novel neuroimaging biomarker, supporting the hypothesis that schizophrenia is accompanied by accelerated aging.
Background
People with schizophrenia develop more chronic diseases at a younger age and die younger than people in the general population. It has been hypothesized that this excess morbidity and mortality could be partially due to accelerated aging in schizophrenia. If true, this would motivate the development of ‘gero-protective’ interventions to reduce chronic disease burden in schizophrenia. However, it has been difficult to test this hypothesis, in part, due to the limited ability to measure aging in samples of people with schizophrenia.
Methods
We utilized a novel neuroimaging biomarker of the longitudinal pace of aging, DunedinPACNI, to test for accelerated whole-body aging in schizophrenia across four neuroimaging datasets (total N = 2,096, 48% female) accessed through the Lieber Institute for Brain Development, the University of Bari Aldo Moro, and the North American Prodrome Longitudinal Study – 3.
Results
We found consistent evidence of faster DunedinPACNI in schizophrenia compared with controls. In contrast, youth at clinical-high risk for psychosis did not have faster DunedinPACNI compared to controls. Unaffected siblings of patients also did not have faster DunedinPACNI than controls. Faster DunedinPACNI in schizophrenia was not explained by tobacco smoking or antipsychotic medication use.
Conclusions
The results support the hypothesis that schizophrenia is accompanied by accelerated aging. Results were inconsistent with some of the most obvious explanations for accelerated aging in schizophrenia (familial risk, smoking, and iatrogenic medication effects). Research should aim to uncover why people who have schizophrenia age rapidly, as well as the utility of early disease-risk monitoring and anti-aging interventions in schizophrenia.
Citation
Whitman, Ethan T., Roberta Passiatore, Annchen R. Knodt, Giulio Pergola, Linda A. Antonucci, Alessandro Bertolino, Giuseppe Blasi, et al. “Replicated Evidence for an Accelerated Rate of Whole-Body Aging in Schizophrenia.” Psychological Medicine 56 (2026): e42. https://doi.org/10.1017/S003329172610333X.